DHEA

Description

Dehydroepiandrosterone (DHEA) is the most abundant corticosteroid hormone in the body, and it acts as a substrate for a variety of other hormones. Current research demonstrates that DHEA levels steadily decline with age after approximately age 25, reaching a low at age 80 of

only about 5% of that of a 20-year-old. DHEA converts to (or stimulates the production of) estrogen, testosterone,

cortisone and many other steroid hormones as needed by the body. Additionally, some cells have specific DHEA receptor sites. Research suggests that DHEA supports the maintenance of normal adrenal and immune function,

bone density, healthy skin, and sexual health. Karuna’s DHEA contains biochemically pure DHEA in amounts

suitable for flexible dosing. We do not use wild yam or other sources claiming to contain “natural” DHEA precursors,

because studies demonstrate these precursors cannot be activated in the human body.

• DHEA is an adrenocortical hormone, the most abundant steroid hormone in the body, which acts as a substrate in the synthesis of a variety of other vital hormones (Lancet 1994;343: 1479-81; Gyncecol Endocrinol 1999; 13:15-25). It is understood that levels of DHEA decrease steadily as the body ages and as a result of declining health (Altern Med Rev 1996;1:60-9; J Sex Med 2011;8:2960-82; Best Pract Res Clin Endocrinol Metab 2011;25:303-19).
• Double-blind trials have reported increases in perceived physical and psychological well-being with DHEA supplementation (J Clin Encocrinol Metab 1994;78:1360; Psychoneuroendocrinology 2000;25:53-68; Arch Gen Psychiatry 2005;62:154-62; Neth J Med 2005;63:300-4).
• Controlled research demonstrates that DHEA supplementation increases epidermal thickness, sebum production, skin hydration, and decreases facial skin pigmentation in the elderly (Proc Natl Acad Sci U S A 2000;97:4279-84).
• Improved immune responses have also been reported after DHEA supplementation (J Gerontol A Biol Sci Med Sci 1997;52:M1-7; Am J Obstet Gynecol 1993;169:1536-9). Taking DHEA helps support normal functioning of the adrenal glands (J Clin Endocrinol Metab 2002;87:2046- 52; N Engl J Med 1999;341:1013-20).
• Improved sexual function in men was reported in a double-blind trial of DHEA (Urology 1999;53:590-5).
• Taking DHEA supports healthy bone density in men and women (Chin Med J (Engl) 2002;115:402-4; Clin Endocrinol (Oxf) 2000;53:561-8).
• Wild yam and other sources claiming DHEA activity are not effective for raising DHEA levels in the human body (JAMA 1996;276:1365-7; Life Sci 1996;59:PL147-57).

Suggested use for adults: One capsule daily, or as directed. Caution: This product should not be taken without professional supervision, especially by patients with a personal or family history of hormone-related conditions, heart disease, mood disorders, or liver dysfunction