- Chondroprotection is an important new concept in rheumatology, referring to the use of agents that actually build and protect the joint surfaces, rather than merely suppressing symptomatic expressions of joint erosion (Rheumatology [Oxford] 2006;45:129-38).
- Glucosamine is an amino sugar and the core building block of mucopolysaccharides, which form a primary component of the ground substance of articular cartilage (Ann Pharmacother 1998;32:574-9).
- Glucosamine sulfate has been shown to help maintain long-term, comfortable function of joint structures (JAMA 2000;283:1469-75; Ann Pharmacother 1998;32:580-7).
- Recent research has shown significant chondroprotection of joint tissues with long-term use of glucosamine sulfate (Ann Pharmacother 2005;39:1080-7; Lancet 2001;357:251-6).
- Other supplements containing glucosamine hydrochloride rather than the sulfate salt do not appear to reliably benefit joint health (N Engl J Med 2006;354:795-808; J Rheumatol 1999;26:2423-30). A report suggested that the sulfate portion might be a key factor in the effectiveness of glucosamine sulfate (Metabolism 2001;50:767-70).
- Potassium chloride (KCl) is a more expensive stabilizer of glucosamine sulfate, but may be preferable to sodium-containing stabilizers.
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