• Natural progesterone may have distinct advantages over synthetic progesterone in terms of safety and effectiveness (Comp Ther 1998;24:336-9).
  • Progesterone, like estrogen, is a hormone that plays an important role in bone metabolism (Endocr Rev 1990;11:386-98).
  • Topical natural progesterone supports bone maintenance (Eur J Nutr 2004;43:246-57), and, when combined with a program of diet, exercise and vitamin and calcium supplementation, supported accumulation of bone mass over a three-year period (Int Clin Nutr Rev 1990; 10:384-91).
  • Topical natural progesterone has been shown in double blind research to promote normal hormonal health during menopause (Obstet Gynecol 1999;94:225-8).
  • A controlled trial of 1/4 teaspoon of cream daily, containing 20 mg transdermal natural progesterone, given to 102 menopausal women, stabilized vasomotor function in the majority of subjects (Obstet Gynecol 1999;94(2):225-8).